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Watch ATLAS the Robot Autonomously Fall Off a Stage. ATLAS is an incredible machine. Theres no way around that. First unveiled in 2. This level of sophistication is exactly why its so damn funny when ATLAS fucks up. Boston Dynamics, the company that builds this incredible robot, recently gave a presentation at the Congress of Future Science and Technology Leaders. It was a pretty normal dog and pony show for the company. ATLAS walked around the stage autonomously, while a human guided Spot. Mini the dogbot across the stage with a controller. Everything was going great until it came time for ATLAS to exit the stage. Even though the robot had successfully pulled off the maneuver in rehearsal, ATLAS really ate it during the actual performance. By the looks of it, ATLAS caught his foot on a stage light and just went ass over elbows through the back curtain. But again, how can we be mad at ATLAS This robot is a true feat of human engineering and ingenuity. Armies of them might even fight wars for us one day. Which brings us back to that Terminator reference. Were probably doomed to die at the feet of ATLAS in the inevitable robot uprising, so we might as well get our yuks in now. TNW. Several real climate scientists contacted by Gizmodo felt Smith was not as up to snuff on his research as he claimed to be, however. These comments reflect the. In case you would like to support Falcosoft to continue developing free software, you can donate here through PayPal. If you cant afford online payments but you like. Why use a SSAS cube What are the advantages of using SSAS Cubes over a regular data warehouse for reporting Note Im not asking why report on a data warehouse instead of a OLTP database. Why You Need a Data Warehouse. Think of it as if I have a reporting tool and have the option to link to tables in a data warehouse or an SSAS cube, what would be the benefits if I linked to the SSAS cube Speed Aggregating Summarizing the data for performance During cube processing SSAS will pre calculate and physically stores aggregations of facts Amounts, Quantities, Money. These aggregations, for example Turnover by Year and Region, are used when a business user queries the cube for this type of information. Therefore the query response time can be very short. When the query is fired SSAS does not have to calculate the outcome from the underlying details like T SQL has to do, but can take the values directly from the stored aggregations. Migrate and move data. Import and Export Data with the SQL Server Import and Export Wizard Microsoft Data Migration Assistant Migrate your SQL Server database to. Use OLAP Services, Excel 2000, and ADO MD to create a local cube slice file from an OLAP cube to work with while youre traveling. 5 Responses to Why use a SSAS cube Pingback Back to basics Why do you need OLAP cubes DataWarehouses for enterprise business reporting systems Paras Doshi Blog. Bring Microsoft SQL Server 2017 to the platform of your choice. Use SQL Server 2017 on Windows, Linux, and Docker containers. Besides that SSAS stores query results in a cache. So the next time the same type of query is fired, it will try to get it from the cache. Speed is especially important for a dashboard that an executive is using to slice and dice as any mouse click that takes more than a few milliseconds to return data will draw complaints. Multidimensional analysis slice, dice, drilldown This very much depends on the tool or front end that is layered over the data, but the idea is that you can very quickly navigate around the data, finding trends, spotting patterns, drilling down, slicing and dicing all key to the concept of cubes. Allowing the user to intuitively wander around the data, not even realising that they performing analysis. Can store Hierarchies.
Best dimensions for a Baseball Batting Cage Baseball batting cages are typically a minimum of 7. This allows proper usage by right handed or left handed batters, without moving the plate. It also allows for safe usage without risking damage to the netting from back swing contact. Selecting the right size for your players usage is dictated by the distance between mound to plate, for the age levels using the cage. Mound to plate distances can range from 3. See our field regulation guide for more info. Length. The optimal length for a baseball batting cage is 7. This allows room on the pitchers end for storage of equipment, such as machines, portable mound, ball carts, etc. Always show Navigation Pane Adobe Community.Ktc. Ive used Adobe products since they produced memory cards for the original pcs.Bookmarks In Adobe Acrobat Pro Dc For Mac' title='Bookmarks In Adobe Acrobat Pro Dc For Mac' />My first purchase of Acrobat was, I believe, version 3 but I cant be certain as not all survived the transition from 5.DOS 2. 0 to Windows 1.It seems that every new version is more difficult to use.As mentioned in this discussion there is no preference for showing the left navigation panel by default.Showing the panel is cumbersome at best 1 View ShowHide Navigation Panes Bookmarks 2 F Lock F4.Some other problems I see is 1 the inability to reduce thumbnails more than one size smaller.That function previously allowed for easier grouping of many pages for a drag and drop into another file.Version 1. 1 was the first I noted with that problem 2 the Acrobat DC screen has a lot of white and shades of grey making it more difficult to find things 3 Beginning with Version 1.This is all I can think of at this time.I know its difficult to please everyone but more users can be please by allowing more preference choices. Resident Evil 4 Trial Edition Debug Console . Does anyone know of a product that does allow the user to set more preferences when opening a pdf file
Free Sex, Free Porn, Free Direct Download. The Atmosphere An Introduction To Meteorology 13Th Edition Ebook more. Tiffany Leiddi Tiffany Leiddi Squirts while Using a Vibrator.Last time we let Julie pretend to be a crewmember, we found it so much easier to convince a hot woman to come back into our truck What we didnt know was that Julie already had a girlfriend Lucky for us, Julie told her girlfriend, Tiffany, what she had been up to, and Tiffany wanted a chance to experience the magical massage truck for herself Julies girlfriend strips down into her black bra and panties while Julie strips off her top and bra to release her full, huge breasts, and the two of them enjoy massaging one another and using up a lot of our warmed massage oil in the processWith such an erotic backdrop for the exploration of each others bodies, its no surprise that this massage starts to turn into a sex massage in public.Julies fingers find their way into Tiffanys shaved and wet pussy, and it doesnt take long until our faux crewmember has brought out the powerful wand massager while another crewmember offers to help by fucking Julies pussy with a dildo at the same time This intense, pleasurable treatment continues until Julie orgasmically squirts all over the bed With Tiffanys orgasm still fresh on her mind, she wants to help her girlfriend feel the same pleasure, and Tiffany focuses all of her attention on Julies pussy.Tiffany alternates sex toys, her fingers, and her mouth on Julies body until Julie has an intense orgasmThis is a lesbian sex scene in public youre going to want to see Read the rest of this entry. Seven Neo Geo Games That Need To Get Ported To Modern Consoles.Every month a smattering of classic Neo Geo games comes to modern consoles thanks to Hamster Corporations Arcade Archives program, but some of the systems most unique and unusual games have yet to make the leap.I pour over the lists of upcoming games every week, and I know full well how easy it is to write off a new release when ACA appears in the title.If youve played any of the recent ones like Super Baseball 2.World Heroes, however, you quickly learn theyre worth taking seriously.In porting the games to modern consoles, Hamster has done its homework, trying to recreate the games classic arcade experience rather than simply emulating the code that eventually made it into the eventual Neo Geo cartridge aimed at home audiences.The list of ACA Neogeo games has been growing for a couple years now, but there are still plenty that havent yet been re released.If youre in the same boat, and dont know if youre a neoNazi, Ive made a helpful guide to determine if you are.To be clear, the neo in neoNazi is.While Im not biased humble brag I have access to every current platform, it would be especially great to be able to play any of the following on my Switch.Cyber Lip. A side scrolling shooter, Cyber Lip falls somewhere between being a Metal Slug clone and a Contra rip off that nevertheless achieves its own unique blend of punk irreverence and chaotic sci fi.Can horror jenk be its own sub genre If so, Cyber Lip fits the category perfectly.How else to describe an unpolished 2.D shooter whose controls are sub par and whose final boss is literally a pair of, wait for it, cyber lips.Soccer Brawl. FIFA and Pro Evo Soccer have perhaps never been better at what they do, but I cant help but feel like soccer video games have left lots of interesting alternatives on the table in their pursuit of big name licenses, realistic facial ticks, and complex physics.Soccer Brawl has none of those things.Its cyborgs kicking the hell out of a bal and rarely hitting the back of the net in the process.There are no fouls though, making it feel like soccer augmented by the brutal logic of a 2.D fighting game. Theres no telling when Nintendo will revive Super Mario Strikers.Id be willing to settle for Soccer Brawl.VMX4Oi6zkg/Um5wyoW_-fI/AAAAAAAABPU/rn29_rkaZD4/s1600/3.jpg' alt='Metal Slug 5 Ps1 Download Neo Geo Full Game' title='Metal Slug 5 Ps1 Download Neo Geo Full Game' />Noregistration upload of files up to 250MB.Not available in some countries.Yesterdays rally of neoNazis, Klansmen, and socalled altright activists predictably devolved into violence.One antifascist protester and two police.Every month a smattering of classic Neo Geo games comes to modern consoles thanks to Hamster Corporations Arcade Archives program, but some of the systems most.Viewpoint. Long before Housemarque had taken over the voxelized twin stick shooter space, a small Japanese outfit called Aicom developed Viewpoint, a game where you collect power ups and fight giant enemy crabs while a wall of fire chases you from behind.It was popular enough that it got ported to the PS1 and was at one point even planned for the Nintendo 6.It had a solid campaign and the games look still holds up, but more than anything the game stands out to this day for its fantastic soundtrack, which made fluctuating between funk, 9.Crossed Swords. A first person fantasy adventure game that plays like Punch Out, there werent many games like Crossed Swords at the time and there havent been many since.Also more giant enemy crabs.Theres even a co op component, since Crossed Swords began as an arcade game.Theres something beautiful in how garish it looks, like a perfect distillation of the cover art for a million fantasy paperbacks you never got around to reading.The Super Spy. Okay, remember how I said Crossed Swords was totally unique Well The Super Spy is somewhat similar, but with the trappings of a late 8.Instead of goblins and crabs you fight brightly dressed terrorists, kind of like if Arnold Schwarzenegger spent all of Commando fighting people cosplaying as the Foot Clan instead of generic South American rebels.Unlike Crossed Swords, however, The Super Spy, for obvious reasons, also includes guns.Mutation Nation. Mad scientists.Exploding labs. Biological experiments.Mutation Nation has it all.While as a side scrolling beat em up it looks a lot like hundreds of other games, Mutation Nation benefits from a plethora of Running Man inspired enemy designs that make each level feel like specific and unique rather than a prolonged brawl with a bunch of repetitive randos.Plus there are power ups that you can unleash, not unlike in the X Men arcade game, that help break up the monotony that plagued so many other beat em ups of the same era.Legend of Success Joe.This last one is a game Ive never actually played, or seen anyone else play.It was never released outside of Japan, and for good reason.Joe might have been successful, along with the manga he was based on, but the game he headlined was not, widely regarded as one of the worst ever put out on the system.So its morbid curiosity driving this pick, rather than quality, nostalgia, or the likelihood of it actually ever happening.Its a boxing game but also a classic beat em up, with fights taking place inside the ring and out on the streets, making it like the Rocky V of video games in more ways than one.Legend of Success Joe is a disaster we should all be able to get our hands on.How to Tell If Youre a Neo Nazi.Internet personalities Baked Alaska and Millennial Matt had a lot of fun at this past weekends white supremacist rallies.Well, until Baked Alaska was maced, I guess.They used tools like Twitter and You.Tube to bring their online followers into the heart of the racist action.But curiously, the two still insist that theyre not neo Nazis.So what the hell is a neo Nazi The rallies in Charlottesville, Virginia were the largest collection of white supremacists in the United States in at least two decades.It left one woman, 3.Heather Heyer, dead and dozens more injured.So its curious to see both Baked Alaska real name Tim Gionet and Millennial Matt real name Matthew Colligan insist that theyre not neo Nazis and that theyve never advocated violence.Im starting to think that maybe they dont know what words mean.If youre in the same boat, and dont know if youre a neo Nazi, Ive made a helpful guide to determine if you are.To be clear, the neo in neo Nazi is simply meant to differentiate between Nazis who were around in the 1.Nazi beliefs today but werent alive during Hitlers time.Sadly, there are still old school Nazis around, like 9.Michael Karkoc who massacred women and children and currently lives in Minnesota. Blue Screen Kernel Power Windows 7 . If you answer yes to any of the questions below, youre a neo Nazi.Do you regularly tweet the 1.Words The so called 1.Words were coined by the late white supremacist David Lane and became a slogan for neo Nazis around the world.The 1. 4 Words read, We must secure the existence of our people and a future for white children.Its not exactly subtle as far as Nazi slogans go.In 1. 98. 4, David Lane helped plot to kill Alan Berg, a Jewish radio talk show host, and acted as the getaway driver when he and his fellow neo Nazi scum shot and killed Berg in his driveway.Lane was sentenced to 1.Baked Alaska loves to tweet the 1.Words. He sends it to President Trump and he makes videos of it.Lots of videos of it.Yesterday, Baked Alaska tweeted his defense of the 1.Words, saying that theres nothing wrong with the slogan and that just because others have used them doesnt change the meaning.Its unclear if he understands the origin of the phrase, but he certainly understands that it means white advocacy.But even if he has no idea that it was coined by a murderous white supremacist thug, its still a poisonous idea that has no place in society.If you tweet the 1.Words youre a neo Nazi.Do you say Hitler did nothing wrongSome people insist that Baked Alaska and Millennial Matt cant be neo Nazis because theyre simply saying outrageous things to get a rise out of people.One of those things is that Hitler did nothing wrong.But at some point youre no longer trolling and youre simply stating what you believe.Millennial Matt has said Hitler did nothing wrong so many times that its become his catchphrase.He says it on radio, in tweets, and in videos.But what the hell does such a phrase mean Adolf Hitler systematically killed millions of Jews in concentration camps during the Holocaust.Saying he did nothing wrong is an endorsement of those deaths.Amazingly, Millennial Matt says that hes never advocated for violence against anyone.In a weepy You. Tube post he whined that people were now threatening his life after he attended the rallies in Virginia.Theres nothing funny about threatening peoples lives, he said.But when you say that Hitler did nothing wrong you are explicitly advocating for violence against nonwhite people.Thats explicitly what Hitler did.Its kind of what hes known for.When you say Hitler did nothing wrong, and you say it so many times that people start to riff on it with jokes about other people who did nothing wrong youre advocating for violence.Thats kind of how this works.If you say Hitler did nothing wrong, youre a neo Nazi.Have you attended a rally with people giving Hitler salutesThe salute goes by a lot of names The Roman salute, the Hitler salute, and the Bellamy salute.But it only has one meaning since it was adopted by the Nazis in the 1.It means youre a neo Nazi.Baked Alaska documented his trip from his home in Los Angeles to Virginia on Twitter and You.Tube for all the world to see.And one of his most frightening videos came from Friday during the infamous tiki torchlight riot.Baked Alaska shot video as his fellow marchers viciously assaulted non violent counter protesters.They can be seen in the video beating people with their torches.The counter protestors later described fearing for their lives.And when Baked Alaska pans around in the crowd, you can clearly see people giving Nazi salutes as they chant white lives matter.If you attend a rally with people giving Hitler salutes, youre a neo Nazi.Do you shout hail victory while carrying a torch in public Did you see footage of people shouting hail victory at the rallies this weekend Its the English translation of sieg heil, the notorious Nazi slogan.Baked Alaska shot video of himself saying just that.They thought we werent going to stand up, Baked Alaska shouts into the camera.Guess what, were standing up for our rightsWere proud to be whiteWere proud to be white, brother, he continued while shaking hands with another white supremacist.Hail victory Hell yeah Thank you, love you guys.If you shout hail victory while carrying a torch in public, youre a neo Nazi.Do you deny that the Holocaust happened Holocaust denial is pretty much textbook neo Nazism.And Millennial Matt peddles in it constantly.At the 5. 2 minute mark during the livestream from Virginia, Millennial Matt encourages viewers to look into revisionist history.Revisionist history often hinges on the belief that historians are lying about the fact that Nazi Germany executed millions of people.The history that they taught you in middle school is not factually accurate, Millennial Matt tells his viewers.The reason that they teach you the civil rights movement and slavery in middle school is because you havent fully developed your brain yet.If you wonder why people emotionally react when you talk about slavery, when you talk about the Holocaust, the reason people emotionally reaction is because they taught this to you before you were even old enough to realize what it is they were teaching you, he continued.The history that they teach you about the Holocaust is not factually accurate whatsoever, he says.The truth is, the Holocaust is one of the biggest hoaxes in world history, he said.Its one of the biggest lies ever perpetrated against the human race.If you deny the Holocaust youre a neo Nazi.Do you believe Americas treatment of Nazis was worse than the Holocaust Aside from believing that the history of the Holocaust isnt accurate, Millennial Matt also believes that Nazi soldiers were treated more poorly than Jews during World War II.He goes so far as to compare Auschwitz, where an estimated 1.If you believe Americas treatment of Nazis was worse than the Holocaust youre a neo Nazi.Do you publish photos of Jewish people you disagree with in gas chambers Baked Alaska also enjoys publishing photoshopped photos of Jewish people he doesnt like in gas chambers.President Trump is often depicted as the one administering the gas, dressed in Nazi regalia.Baked Alaska was even temporarily banned for doing it, but insists hed do it all over again.If you publish photos of Jewish people you disagree with in gas chambers youre a neo Nazi.Do you have a photo of Joseph Goebbels in your Twitter header Youre never going to guess what WWII figure Millennial Matt has in his Twitter header.Yes, thats Joseph Goebbels, easily one of the most evil men in history and responsible for the deaths of millions of Jews.Oh, and former Grand Wizard of the Ku Klux Klan David Duke is also in there.Ironically, no doubt.If you have a photo of Joseph Goebbels in your Twitter header youre a neo Nazi.Have you marched with people who physically assault others because of their race New footage has emerged overnight of the vicious assault endured by 2.Deandre Harris at the hands of white supremacists in a parking garage.Its brutal to watch.Me and about five of my friends were out protesting.We thought the racists left, but at one point they came back.Everyone was exchanging words with the group, but then the KKK and white supremacists just rushed us, Harris told The Root.Harris is lucky to be alive. News Bulletin of International Holo.Genomics Society. Arcgis Server 10 Software Download . Table of ContentsJul 1.Whole genome sequencing reveals mutations outside of protein coding regionsJul 0.Psst, the human genome was never completely sequenced.Some scientists say it should beJun 2.Failed To Complete Installation 1628 Sap Business One Training' title='Failed To Complete Installation 1628 Sap Business One Training' />Tender impulse provides Security Systems tenders, contracts and biddings information and invitations.To find more latest Government tenders get in touch 91 97681.Surname First Names Number History AARDEN PAUL MICHAEL 2354 1997 General manager of Sun Microsystems for South and Central Africa, based in Johannesburg.The history of Sudbury, Massachusetts, 16381889.Digitized by the Internet Archive in 2009 with funding from Allen County Public Library Genealogy Center.Web oficial de la Universidade da Corua.Enlaces a centros, departamentos, servicios, planes de estudios.University of Debrecen, Hungary and BGI Group sign MOU China penetrates Central European Genome MarketJun 1.Fractal Cancer Fractal Genome Critical Juncture for NIH and its National Cancer InstituteJun 1.Lung Cancer a Fractal Viewpoint why is Academia hesitant to embrace disruptive breakthroughsJun 0.Fractal Cancer Sokolov Chapter in Cancer Nanotechnology TextbookMay 3.Researchers discover hundreds of unexpected mutations from new gene editing technologyMay 1.The future of forensic neurosciences with fractal geometryMar 0.Why Genomics Isnt All Its Cracked Up To BeFeb 2.Craig Venter Mapped The Genome.Now Hes Trying To Decode DeathFeb 1.China Looks for Fractal Experts request from HohhotFeb 1.Bill Gates Bioterrorism could kill more than nuclear war but no one is ready to deal with it except a few unmentioned.Feb 1. How Trump can make the most of a nonpartisan cancer moonshotFeb 1.China aggressively challenges US lead in precision medicineFeb 0.Patriots cheerleader and MIT researcher, Theresa Oei does it all the new generation leaps over the nonsense of Junk DNAFeb 0.NIH to expand critical catalog for genomics researchFeb 0.The mysterious 9.Scientists look to shine light on the dark genomeFeb 0.Debunking the Junk DNA TheoryFeb 0.Two Infants Cured of Terminal Cancer by Breakthrough Gene Editing TherapyJan 3.Could Cancer Drugs Treat AutismJan 2.Identification of neutral tumor evolution across cancer types Tumor Evolution Is FractalJan 2.The Trillioner is Getting ITJan 1.Illumina Taps Garret Hampton, One of the Worlds Leading Clinical Genomics Experts, to Head its Clinical Genomics UnitJan 1.Illumina Promises To Sequence Human Genome For 1.But Not Quite YetJan 0.Craig Venter Used Own Posh Health Clinic To Diagnose His CancerJan 0.Illumina Strikes Deals With Philips, IBM to Interpret Cancer Genomic DataJan 0.Grail Seeks to Raise 1.B in Series B Illuminas Stake to Fall Below 2.PercentJan 0. 5 Biden looks to continue cancer work Moon Shot exploded before launchJan 0.Hungary Launches National Oncogenomics Program2.Dec 1. 5 Washington D.C. making historyDec 1.Mr. President Elect, The Genome is Fractal Mathematical analysis reveals fractal architecture of the human genomeDec 1.Maryland congressman in running to head NIHDec 0.Hope gratis full sequencing and interpretation by IlluminaNov 2.Moon Shots Genome.Web writesNov 2. The Massive Next Big Thing National Genome ProjectsNov 2.The Third Hungarian NotationOct 0.Non coding portions of genome are found to play role in cancerSep 2.Microsoft initiatives treat cancer as a computing problemSep 1.Junk DNA tells mice and snakes how to grow a backboneSep 1.The Oncoming Double Disruption of Technology of New School Genomics Smidg.ION by Oxford NanoporeSep 0.Dr. Pellionisz comments on the 7 R D articles posted on Labor Day, 2.AndrasatPellioniszdotcomSep 0.Multiscale modeling of cellular epigenetic states stochasticity in molecular networks, chromatin folding in cell nuclei, and tissue pattern formation of cellsSep 0.Fractal Dimension of Tc 9.DTPA GSA Estimates Pathologic Liver Injury due to Chemotherapy in Liver Cancer PatientsSep 0.Unique fractal evaluation and therapeutic implications of mitochondrial morphology in malignant mesotheliomaSep 0.Systems Medicine of Cancer Bringing Together Clinical Data and Nonlinear Dynamics of Genetic NetworksSep 0.ASXL2 promotes proliferation of breast cancer cells by linking ER to histone methylationSep 0.Researchers identify two proteins important for the demethylation of DNASep 0.Mathematical Modelling and Prediction of the Effect of Chemotherapy on Cancer CellsSep 0.Breast cancer researchers look beyond genes to identify more drivers of disease developmentAug 3.HPE Synergy Shows Promise And Progress With Early AdoptersAug 2.Illumina Can GRAIL Deal A Death Blow In The War Against CancerAug 1.Precision medicine Analytics, data science and EHRs in the new ageAug 1.Stanford Medicine, Google team up to harness power of data science for health careAug 0.Leroy Hood 2. 00.The Genome is a System needs some system theoryAug 0.What if Dawkins Selfish Gene would have been Selfish Fracto.GeneJul 2. 5 DNA pioneer James Watson The cancer moonshot is crap but there is still hopeJul 2.Science Cover Issue 2.July 2. 2 with Fractal folding of DNA and of ProteinsJul 2.CRISPR Immunotherapy aheadJul 2.Qatari genomes provide a reference for the Middle EastJul 1.CIA Chief Claims that Genome Editing May Be Used For Biological WarfareJul 1.Are Early Harbingers of Alzheimers Scattered Across the GenomeJul 0.Independence Day A 2.Apple as a teenager wants to make a yearly blood test to diagnose cancer and he just got 5.Silicon Valley VCs to pull it offJun 2.President Obama Hints He May Head to Silicon Valley for His Next JobJun 1.Is This the Biggest Threat Yet to IlluminaMay 2.Big talk about big data, but little collaborationApr 2.Can Silicon Valley cure cancerApr 1.Life Code Bioinformatics The Biggest Disruption EverJuan EnriquezApr 0.Craig Venter We Are Not Ready to Edit Human Embryos YetMar 2.Big Data Meets Big Biology in San Diego on March 3.The AgendaMar 0. Illumina Forms New Company to Enable Early Cancer Detection via Blood Based ScreeningMar 0.Illumina CEO Jay Flatley Built The DNA Sequencing Market.Now Hes Stepping DownMar 0.CRISPR gene editing is just the beginningMar 0.Geneticists debate whether focus should shift from sequencing genomes to analysing function.Feb 1. Top U. S. Intelligence Official Calls Gene Editing a WMD ThreatFeb 0.Craig Venter We Are Not Ready to Edit Human Embryos YetFeb 0.UK scientists gain licence to edit genes in human embryosJan 3.Why Eric Lander morphed from science god to punching bagJan 2.Easy DNA Editing Will Remake the World.Buckle Up. Jan 2.Genome Editing and the Future of Human SpeciesJan 2.Chinese scientists create designer dogs by genetic engineeringJan 1.Gene edited pigs may soon become organ donorsJan 1.New life for pig to human transplantsJan 1.Genome Editing What is the code that we are editingJan 0.CRISPR helps heal mice with muscular dystrophyJan 0.Credit for CRISPR A Conversation with George Church2.For archived Holo.Genomics News articles see Archives above.NEWSWhole genome sequencing reveals mutations outside of protein coding regions.Mutations in gene promoters reveal specific pathway pathologies in pancreatic cancer.May 8, 2. 01. 7Cold Spring Harbor Laboratory.Summary A new wave of research is significantly improving our ability to target cancer cells by studying the other 9.DNA in human chromosomes, beyond the 2 percent that encodes proteins.Researchers looked at cells sampled from 3.Over the last decade, it has made good sense to study the genetic drivers of cancer by sequencing a tiny portion of the human genome called the exome the 2 of our three billion base pairs that spell out the 2.If cancer is a disease precipitated by changes in genes, after all, we need to know lots about how and when different genes change in the many distinctive subtypes of cancer.But a new wave of research, exemplified by a study published in Nature Genetics by a team at Cold Spring Harbor Laboratory CSHL, is significantly improving our ability to target cancer cells by studying the other 9.DNA in human chromosomes, sometimes called the genomes dark matter.Research led by Michael Feigin, Ph.D., a postdoctoral researcher in the laboratory of CSHL Professor David Tuveson, M.D., Ph. D., looked closely at cells sampled from 3.Importantly, the full genome of the sampled pancreatic cancer cells was sequenced, not just the 2 that comprises the exome.This enabled Feigin and colleagues including computational biologist Tyler Garvin, Ph.D., formerly of Adjunct Associate Professor Michael Schatzs lab, to focus narrowly on genome segments called gene promoters.These segments of DNA typically lie adjacent to, but not within, the sequences of the genes that they regulate. |
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